Worming out molecular secrets kɔfɛ jɛkulu ka kɛwalew

ka bɔ mɔgɔ kelen-kelen bɛɛ la ka taa jɛkulu la : sariya nɔgɔmanw fanga

dacogo la , ko minnu bɛ mɔgɔ ninakili bɔ kosɛbɛ, olu dɔw tɛ bɔ cɛmancɛ cikan dɔ la nka u bɛ bɔ mɔgɔ nɔgɔmanw ka jɛ-ka-baara la . Starling kulu dɔ min bɛ ka wuli san fɛ, jɛgɛw ka lakɔli min bɛ ka wuli i n’a fɔ kelen, ani wulu kulu min bɛ ka denso gɛlɛn dɔ jɔ — ninnu bɛɛ ye misaliw ye jɛkulu ka kɛwalew la minnu bɛ ka bɔ kɛnɛ kan. A bɛ san tan caman bɔ, dɔnnikɛlaw bɛ sariya jɔnjɔnw ɲini minnu bɛ o sigida gɛlɛnw ɲɛminɛ. Kabako don, gundo ninnu dabɔli misali barikama dɔ ye danfɛn majiginlen ye : wuluwulu bulama Caenorhabditis elegans. Nin kɔnɔnin fitininw bɛ ɲɔgɔn sɔrɔ cogo min na, ɲininikɛlaw bɛ ka fɛnɲɛnamaw ka gundo sɛgɛsɛgɛ cogo min na, minnu b’a ɲɛfɔ cogo min na fɛnɲɛnamaw ka fɛn nɔgɔmanw bɛ kuluw ka fanga caman sɔrɔ, o ye sariyakolo ye min nɔ ka bon kosɛbɛ ka tɛmɛ laboratuwari kan.

Ntumu ye misali ye sigida gundo la

C. Bamako, Mali. elegans ye ɲɛnamayako ɲinini nafama dɔ ye k’a sababu kɛ a nɔgɔya ye, a farikolo jɛlen don, ani a karti dafalen na ni senfagabana ye. Hali n’u bɛ kalan tuma caman na u kelen-kelen bɛɛ la, o kɔnɔw bɛ sigida taabolo danfaralenw fana jira, i n’a fɔ u bɛ ɲɔgɔn lajɛ ɲɔgɔn fɛ walasa ka balo sɔrɔ walima ka u jɛnsɛn ɲɔgɔn fɛ walasa ka dumuni sɔrɔyɔrɔ kura sɔrɔ. Nin jiginni in ka bɔ kelennasigi la ka taa kulu sigili la, o tɛ kɛ k’a sɔrɔ a ma kɛ cogo si la; a bɛ ɲɛminɛ ni dusukunnataw taamasiyɛn kɛrɛnkɛrɛnnenw ni molekiyɔmu siraw ye. Ɲininikalaw bɛ se ka kɔnɔsogonin ka jamu sɛgɛsɛgɛ tigitigi ani ka fɛn minnu bɛ sɔrɔ kuluw ka kɛwalew la, olu kɔlɔsi, o b’a to u bɛ se ka tigɛli kɛ ka bɔ mɔlikulu kelen na ka taa wale dɔ la min bɛ kɛ koloni bɛɛ kɔnɔ. O b’a to kɔnɔ bɛ kɛ misali ye min ɲɔgɔn tɛ, walasa ka jɛkulu ka latigɛw jɔcogo tigɛtigɛ.

Molekuli taamasiyɛn minnu bɛ jama bilasira

ntumuw jɛ-ka-baara kɛcogo dusukun na, kemikɛli taamasiɲɛw bɛ yen. Kɔnɔnatumuw b’u cogoya n’u ka sigida cogoyaw fɔ feromɔniw fɛ — kasa fɛnɲɛnamafagalanw minnu bɛ bɔ u lamini na. Kɔlɔsiliw y’a jira ko feromɔni ɲagaminen kɛrɛnkɛrɛnnenw bɛ se ka kɛ sababu ye ka ɲɔgɔn dalajɛ, ka kɛ "to yan" taamasiɲɛ ye ni dumuni ka ca. O kɔfɛ, taamasiyɛn wɛrɛw bɛ jɛnsɛnni bila, ka dusu don jamanadenw kɔnɔ u ka mara kuraw ɲini. O taamasiɲɛw dɔnni bɛ kɛ ni fɛn minɛbagaw ni senfagabana ka ɲɔgɔndɛmɛ gɛlɛn ye, o kɔfɛ, u bɛ kɔnɔna farikoloɲɛnajɛ siraw baara. Misali la, a jirala ko insuline hormone, n’o ye farikoloɲɛnajɛ ɲɛnabɔbaga jɔnjɔn ye, o fana bɛ nɔ bila sigida balo la. Ni o molekiyɔmu taamasiɲɛw tiɲɛna, kulu ka hakili jɛlen bɛ tiɲɛ, o bɛ na ni kɛwalew ye minnu tɛ labɛn ani minnu tɛ baara kɛ.

• Hakilila-minɛnw : farikolojɔlifɛn minnu bɛ kɔnɔsogonin kan , olu bɛ feromɔni kɛrɛnkɛrɛnnenw dɔn , u bɛ kɛ kumaɲɔgɔnya senfɛ fɔlɔ ye .
• Sɛrɛkiliw : senfagabana minnu bɛ ɲɔgɔn cɛ , olu kulu misɛnninw bɛ dusukunnataw kunnafoniw baara , ka jaabi dɔ latigɛ .
• Sɔgɔsɔgɔninjɛ ni ɔrimɔni : Molecules i n'a fɔ serotonin ni insuline bɛ senfagabana latigɛ baara kɛ farikolo wale ye , ka lamaga ni farikoloɲɛnajɛ caman sɛmɛntiya .
• Jɛnkulu jiracogo : Yɛlɛma kuntaalajan minnu bɛ kɛ kuluw ka kɛwalew la , olu bɛ se ka sinsin ni jamu kɛrɛnkɛrɛnnenw dabɔli walima u fagali ye ka kɛɲɛ ni sigida taamasiyɛnw ye .

ka bɔ ɲɛnamayako la ka taa jago la : Labɛn kura bɔlenw sariyakolow

Kalansen minnu bɛ bɔ C. elegans ye ntalen barikama ye hadamadenw ka jɛkuluw bolo. Jago min bɛ ɲɛtaa sɔrɔ, i n’a fɔ kɔnɔw ka kulu, o bɛ a jigi da a kɔnɔmɔgɔ kelen-kelen bɛɛ ka wale jɛlen kan, k’a sɔrɔ a mago tɛ micromanagement la ka bɔ sanfɛ. O kun ye ka sariya jɛlenw sigi senkan, minnu ka nɔgɔn, ani kumaɲɔgɔnya sira ɲumanw, minnu b’a to hakili ni baarakɛcogo ɲuman bɛ bɔ jɛkulu kɔnɔ.

"Ntumu kulu cɛɲi bɛ a hakili tilalen de la. Wolo kelen tɛ kuntigiya la, o bɛɛ n'a ta, kulu bɛ laɲini gɛlɛnw sɔrɔ molekiyɔmu sariya jɛlen dɔ sababu fɛ. Nin ye dantigɛli laban ye sigida la min bɛ se ka muɲu ani min bɛ se ka ladamu."(Blockquote>) – Sitimɛw ka ɲɛnamayako dɔnbaga dɔ

O yɔrɔ de la, kɛnɛba min bɛ i n' a fɔ Mewayz, o b' a nafa jira . Mewayz bɛ "molecules framework" numérique di jagokɛla dɔ ma. A yɔrɔw modulariw — i n’a fɔ porozɛw nɔfɛtaamakɛlaw, kumaɲɔgɔnya yɔrɔw, ani kunnafonidilanw — bɛ baara kɛ i n’a fɔ dusukunnataw sɔrɔyɔrɔw ani hakililata sɛrɛkiliw, o b’a to kunnafoniw bɛ taa ɲɔgɔn fɛ jɛkuluw ni ɲɔgɔn cɛ cogo la min tɛ fɛn tiɲɛ. Ni a ye baarakɛcogo jɛlenw sigi sen kan (jagokɛcogo min bɛ bɛn sariya nɔgɔmanw ma), Mewayz bɛ se ka mɔgɔ kelen-kelen bɛɛ dɛmɛ u ka baara kɛ u yɛrɛma, nka u bɛ baara kɛ ɲɔgɔn fɛ ka ɲɛsin laɲini kelenw ma. Plateforme in b’a to taamasiyɛn ɲumanw ka se mɔgɔ bɛnnenw ma waati bɛnnen na, ka sɔrɔko ni kokuradon suguya min bɛ bɔ kɛnɛ kan, o sabati min bɛ jɛkulu dɔ ɲɛfɔ min bɛ baara kɛ kosɛbɛ.

Kunnafoni : jɛ-ka-baara seko dabɔli

wuluwulu majiginlen b' an kalan ko gɛlɛya ni sigikafɔ bɛ se ka bɔ nɔgɔya la . Gundo molekiyɔmu minnu bɛ jɛkulu ka kɛwalew kɔfɛ, olu bɛ tiɲɛ dɔ jira diɲɛ bɛɛ kɔnɔ: sigida nafamaw jɔlen bɛ kumaɲɔgɔnya jɛlenw ni latigɛw kan minnu bɛ kɛ jamana kɔnɔ. Ni an ye o sariyakolow faamuya, an bɛ se ka jɛkuluw, dugubaw ani fɛɛrɛ ɲumanw dilan. Jagokɛlaw ka diɲɛ kɔnɔ, ka baara kɛ ni baarakɛminɛn modulari ye i n’a fɔ Mewayz, o b’a to tɔnw bɛ se ka nin ɲɛnamaya sariyakolo ninnu don u kɔnɔ, ka mɔgɔ kelen-kelen kulu dɔ sɛmɛntiya ka kɛ jɛkulu hakilitigi ye tiɲɛ na ani min bɛ se ka ladamu, min labɛnnen don ka ɲɛtaa sɔrɔ sigida la min bɛ Changé tuma bɛɛ.

Ɲininkali minnu bɛ kɛ tuma caman na

ka bɔ mɔgɔ kelen-kelen bɛɛ la ka taa jɛkulu la : sariya nɔgɔmanw fanga

dacogo la , ko minnu bɛ mɔgɔ ninakili bɔ kosɛbɛ, olu dɔw tɛ bɔ cɛmancɛ cikan dɔ la nka u bɛ bɔ mɔgɔ nɔgɔmanw ka jɛ-ka-baara la . Starling kulu dɔ min bɛ ka wuli san fɛ, jɛgɛw ka lakɔli min bɛ ka wuli i n’a fɔ kelen, ani wulu kulu min bɛ ka denso gɛlɛn dɔ jɔ — ninnu bɛɛ ye misaliw ye jɛkulu ka kɛwalew la minnu bɛ ka bɔ kɛnɛ kan. A bɛ san tan caman bɔ, dɔnnikɛlaw bɛ sariya jɔnjɔnw ɲini minnu bɛ o sigida gɛlɛnw ɲɛminɛ. Kabako don, o gundo ninnu dabɔli misali barikama dɔ ye danfɛn majiginlen ye: wuluwulu bulama Caenorhabditis elegans. Nin kɔnɔnin fitininw bɛ ɲɔgɔn sɔrɔ cogo min na, ɲininikɛlaw bɛ ka fɛnɲɛnamaw ka gundo sɛgɛsɛgɛ cogo min na, minnu b’a ɲɛfɔ cogo min na fɛnɲɛnamaw ka fɛn nɔgɔmanw bɛ kuluw ka fanga caman sɔrɔ, o ye sariyakolo ye min nɔ ka bon kosɛbɛ ka tɛmɛ laboratuwari kan.

Ntumu ye misali ye sigida gundo la

C. elegans ye ɲɛnamayako ɲinini nafama dɔ ye k’a sababu kɛ a nɔgɔya ye, a farikolo jɛlen don, ani a karti dafalen na ni senfagabana ye. Hali n’u bɛ kalan tuma caman na u kelen-kelen bɛɛ la, o kɔnɔw bɛ sigida taabolo danfaralenw fana jira, i n’a fɔ u bɛ ɲɔgɔn lajɛ ɲɔgɔn fɛ walasa ka balo sɔrɔ walima ka u jɛnsɛn ɲɔgɔn fɛ walasa ka dumuni sɔrɔyɔrɔ kura sɔrɔ. Nin jiginni in ka bɔ kelennasigi la ka taa kulu sigili la, o tɛ kɛ k’a sɔrɔ a ma kɛ cogo si la; a bɛ ɲɛminɛ ni dusukunnataw taamasiyɛn kɛrɛnkɛrɛnnenw ni molekiyɔmu siraw ye. Ɲininikalaw bɛ se ka kɔnɔsogonin ka jamu sɛgɛsɛgɛ tigitigi ani ka fɛn minnu bɛ sɔrɔ kuluw ka kɛwalew la, olu kɔlɔsi, o b’a to u bɛ se ka tigɛli kɛ ka bɔ mɔlikulu kelen na ka taa wale dɔ la min bɛ kɛ koloni bɛɛ kɔnɔ. O b’a to kɔnɔ bɛ kɛ misali ye min ɲɔgɔn tɛ, walasa ka jɛkulu ka latigɛw jɔcogo tigɛtigɛ.

Molecules Cues minnu bɛ jama bilasira

ntumuw jɛ-ka-baara kɛcogo dusukun na, kemikɛli taamasiɲɛw bɛ yen. Kɔnɔnatumuw b’u cogoya n’u ka sigida cogoyaw fɔ feromɔniw fɛ — kasa fɛnɲɛnamafagalanw minnu bɛ bɔ u lamini na. Kɔlɔsiliw y’a jira ko feromɔni ɲagaminen kɛrɛnkɛrɛnnenw bɛ se ka kɛ sababu ye ka ɲɔgɔn dalajɛ, ka kɛ "to yan" taamasiɲɛ ye ni dumuni ka ca. O kɔfɛ, taamasiyɛn wɛrɛw bɛ jɛnsɛnni bila, ka dusu don jamanadenw kɔnɔ u ka mara kuraw ɲini. O taamasiɲɛw dɔnni bɛ kɛ ni fɛn minɛbagaw ni senfagabana ka ɲɔgɔndɛmɛ gɛlɛn ye, o kɔfɛ, u bɛ kɔnɔna farikoloɲɛnajɛ siraw baara. Misali la, a jirala ko insuline hormone, n’o ye farikoloɲɛnajɛ ɲɛnabɔbaga jɔnjɔn ye, o fana bɛ nɔ bila sigida balo la. Ni o molekiyɔmu taamasiɲɛw tiɲɛna, kulu ka hakili jɛlen bɛ tiɲɛ, o bɛ na ni kɛwalew ye minnu tɛ labɛn ani minnu tɛ baara kɛ.

Ka bɔ ɲɛnamayako la ka taa jago la : Labɛn kura bɔlenw sariyakolow

Kalan minnu bɛ sɔrɔ C. elegans fɛ, olu ye ntalen barikama ye hadamadenw ka jɛkuluw bolo. Jago min bɛ ɲɛtaa sɔrɔ, i n’a fɔ kɔnɔw ka kulu, o bɛ a jigi da a kɔnɔmɔgɔ kelen-kelen bɛɛ ka wale jɛlen kan, k’a sɔrɔ a mago tɛ micromanagement la ka bɔ sanfɛ. O kun ye ka sariya jɛlenw sigi senkan, minnu ka nɔgɔn, ani kumaɲɔgɔnya sira ɲumanw, minnu b’a to hakili ni baarakɛcogo ɲuman bɛ bɔ jɛkulu kɔnɔ.

Kunnafoni : jɛ-ka-baara seko dabɔli

wuluwulu majiginlen b' an kalan ko gɛlɛya ni sigikafɔ bɛ se ka bɔ nɔgɔya la . Gundo molekiyɔmu minnu bɛ jɛkulu ka kɛwalew kɔfɛ, olu bɛ tiɲɛ dɔ jira diɲɛ bɛɛ kɔnɔ: sigida nafamaw jɔlen bɛ kumaɲɔgɔnya jɛlenw ni latigɛw kan minnu bɛ kɛ jamana kɔnɔ. Ni an ye o sariyakolow faamuya, an bɛ se ka jɛkuluw, dugubaw ani fɛɛrɛ ɲumanw dilan. Jagokɛlaw ka diɲɛ kɔnɔ, ka baara kɛ ni baarakɛminɛn modulari ye i n’a fɔ Mewayz, o b’a to tɔnw bɛ se ka nin ɲɛnamaya sariyakolo ninnu don u kɔnɔ, ka mɔgɔ kelen-kelen kulu dɔ sɛmɛntiya ka kɛ jɛkulu hakilitigi ye tiɲɛ na ani min bɛ se ka ladamu, min labɛnnen don ka ɲɛtaa sɔrɔ sigida la min bɛ Changé tuma bɛɛ.